Diabetes remission type 1

diabetes remission type 1

Description Summary: Background Metabolic surgery has beneficial metabolic effects, including remission of type 2 diabetes.

diabetes remission type 1

We hypothesized that duodenojejunal bypass DJB surgery can protect against development of type 1 diabetes T1D by enhancing regulation of cellular and molecular pathways that control glucose homeostasis.

At T1D diagnosis, a subcutaneous insulin pellet was implanted, oral glucose tolerance test was performed 21 days later, and tissues were collected 25 days after onset of T1D.

Fecal microbiota composition was analyzed by 16S V4 sequencing.

diabetes remission type 1

Results Postoperatively, DJB rats diabetes remission type 1 less than sham rats There was no difference in oral glucose tolerance, fasting and stimulated plasma insulin and c-peptide levels, and immunohistochemical analysis of insulin-positive cells in the pancreas. DJB rats needed 1.

diabetes remission type 1

DJB rats had reduced markers of metabolic stress in liver. After DJB, the fecal microbiome changed significantly, including increases in Akkermansia and Ruminococcuswhile the changes were minimal in sham rats.

diabetes remission type 1

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