Diabetes mellitus type 1 investigations

diabetes mellitus type 1 investigations
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Department of Paediatrics Budapest, Approximately 0. Although rare mono or oligogenic forms of T1DM exist, the inheritance pattern of common forms of the disease is polygenic.


The remaining susceptibility genes have much lower overall contribution to diabetes risk. Identification and functional analysis of additional loci will provide pathophysiological insights necessary for the development of preventive interventions and individual risk prediction.

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Studies over the last 20 years have examined the possible involvement of cytokines in the pathogenesis of T1DM. A variety of cytokines have been found to be expressed diabetes mellitus type 1 investigations the insulitis lesion of autoimmune diabetes-prone non-obese diabetic NOD mice and Biobreeding BB rats, as well as in the pancreata of humans with T1DM.

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med.

Coeliac disease CD is characterised by severe inflammation of the small intestine, which is triggered by gliadin. Prevalence of celiac disease in type 1 diabetes mellitus children is higher than that in nondiabetic children.

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This phenomenon is probably because of several common immunpathogenic factors. The environment of the ongoing diabetic autoimmunity may be a stimulant to the development of CD, a disease that possesses autoimmune features.

What is Diabetes Mellitus? - Understanding Diabetes - Diabetes Type 1 and Type 2

These polymorphisms or combinations of polymorphisms might play an essential role in the pathogenenesis of T1DM, CD or both by influencing the quality or the quantity of the protein coded by the gene.

TNF-α and IL-1β are pro-inflammatory cytokines produced primarily by activated macrophages that infiltrate the islets during the pathogenesis of diabetes. IL-6 may contribute not only to inflammatory processes that occur in autoimmune diabetes, but also to cellular neogenesis, which may indicate a role in tissue repair.

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The expression of heat shock protein HSP is probably one of the most conservative mechanisms of cellular protection from stress and HSPs have been indicated to play a cytoprotective role against a variety of toxic mediators. The presence of A allele was associated with autoimmune and inflammatory diseases, however the role of TNFα G A polymorphism in the excretion of TNFα is controversial.

The carrier state of the IL-1β T allel is associated with enhanced cytokine production. Functional SNPs of CD14 and TLR4 might alter the innate mucosal immune response to bacterial antigens, thereby eliciting a stronger reaction to infection. The consequent inflammation in the jejunal mucosa might disrupt the intestinal 3 4 permeability barrier, leading to an increased gluten load in the lamina propria and to the development of CD. TLR G allel carrier state is associated with less amount of inflammatory cytokines.

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The control groups represented healthy hungarian blood donors and term infants fifth postnatal day metabolic screening. Statistical analysis Hardy-Weinberg equilibrium was calculated to evaluate the relationship between gene frequencies and genotype frequencies.

Chi square test and Fisher test were used to compare categorical data.

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For calculations SPS The higher IL-6 production associated with the G allele in Langerhans islets, might have a protective effect against the autoimmune process and might delay the destruction of the β-cells.

We found a significantly higher rate of carriers of TNFα A allele in the histology-proven CD group than in the non-cd group.


The significance of this finding is still unclear. The functional importance of G A polymorphism has not been clarified yet.

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CD14 is an important factor of inflammation in coeliac disease, but may have some protective effect in the pathogenesis of T1DM. Our results confirm that for CD the major susceptibility factor is DQ2, while for type 1 diabetes DQ8 is a stronger susceptibility factor than DQ2 also in the Hungarian population.

Zsuzsanna Zeher, Márta Szilvágyi and Dr. Antal Dezsıfi.

Full size table Experimental design A To investigate the effect of DDW on metabolic changes occur in diabetes, diabetic and control rats were divided into two main groups: half of the animals were given DDW 25 ppm Dand the other half received normal tap water ppm Dboth provided ad libitum. To determine whether DDW exerts its effects, at least partially, by modifying the action of insulin, diabetic rats were further divided into subgroups according to insulin treatment. The control rats did not receive insulin treatment. We did not want to achieve euglycaemia by insulin treatment, but to prevent severe acute complications only.

Thanks are axpressed to Dr. George Füst for technical help in statistics. Diabetes mellitus type 1 investigations influences of the TNFα and interleukin-1β polymorphisms. Hungarian Diabetes Association Medicina Thoracalis, 60 2 : Sipos, P. Aneszteziológia és Intenzív Terápia, 33 2 : Janecskó M. Aneszteziológia és Intenzív Terápia 29, Suppl. III : Janecskó M. Aneszteziológia és Intenzív Terápia, 28 Suppl. In: Pénzes I, Lencz L edit.

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Alliter, Budapest, Hermann Cs: Katecholaminok és vazoaktív terápia. Alliter, Budapest, Hermann Cs: Gázcsere. In: Pénzes Diabetes mellitus type 1 investigations, Lorx A edit.

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Medicina, Budapest, Hermann Cs: Tüdıkeringés. Medicina, Budapest,

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